Oral Biosciences & Medicine
Oral Biosci Med 1 (2004), No. 4     7. Feb. 2005
Oral Biosci Med 1 (2004), No. 4  (07.02.2005)

Page 249-257


The Significance of Gingival Crevicular Fluid and IL-1ß, TNF-α and PGE2 in Periodontal Disease. A Literature Review
Younis, Mahmoud N. / Machtei, Eli E. / Oetlinger-Barak, Orit / Peled, Micha
To review the literature regarding cytokines and PGE2 levels in gingival crevicular fluid (GCF) in healthy and diseased periodontium.
A Medline search ending at March 2004 was performed, in the English literature, regarding IL-1ß, TNF-α and PGE2 in the GCF, and the data was reviewed systematically.
Low levels of these markers were reported in healthy periodontium. Significant increase in the amount of IL-1ß and PGE2 was noted in gingivitis and periodontitis. Most of the studies have shown that there is a marked decrease in IL-1ß and PGE2 levels of periodontal disease patients after therapy, while inconsistent results were found for TNF-α.
The IL-1ß, TNF-α and PGE2 levels may be indicative of periodontal status, and amount rather than concentration being more reliable in reflecting the real status of the periodontium.

Keywords: ß, TNF-α